I can understand arrest of recombination (in sexual chromosomes for example) caused by a chromosome inversion. In which case, it seems to me that only heterozygous (the two chromosoms have sequences that point into opposite direction) individual does not recombine the particular sequence which inverted.
But, if I'm not mistaken (I have no reference to provide!), most of the time a variance in recombination rate for a given sequence is observed in a population, this variance is associated with a locus that is not necessarily closely (physically) linked to the sequence of interest. Is it correct?
How can a mutation in, say chromosome 2, can influence the recombination rate of a sequence in chromosome 8? I am not asking the evolutionary reason(s) of that (although they deeply interest me!) but the mechanistic (molecular) pathways causing this variance in recombination rate.