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How is movement of proteins and lipids between different domains of cell membrane prevented?

Why is the noncytosolic layer not able to do lateral movements between domains but cytosolic layer is able to do so?

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First of all, often it is not. Many receptors for example move around the membrane. You might want to have a look at wikipedia's entry on lipid rafts though. –  terdon Sep 3 '13 at 17:45
@terdon Yes , I know that it is not always restricted. I wanted to know what prevents movement in the restricted ones. –  biogirl Sep 4 '13 at 16:34
Did you read the link I gave you? That is one of the mechanisms. –  terdon Sep 4 '13 at 16:35
Yup.Thank you... –  biogirl Sep 4 '13 at 16:38

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