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In many animals GTP is produced in citric acid cycle. While in plants,bacteria and some animals ATP is produced. Why is this so ? What is the advantage ?

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This step is catalyzed by succinyl-CoA synthase which has two different isoforms- one which produces GTP while the other produced ATP. It seems from this study that predominantly anabolic tissues prefer the GTP-producing form whereas the predominantly catabolic tissues use the ATP-producing from. In the same paper they discuss that GTP is important for protein synthesis and it is also involved in production of phospho-enolpyruvate by PEP-carboxykinase in mitochondria; therefore playing an important role in anabolic processes.

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