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I am really confused as to when kinetochores are attached to centromeres. Are they attached soon after replication or after condensation ?

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after condensation.. – WYSIWYG Sep 9 '13 at 4:32
@WYSIWYG Would you like to elaborate and write an answer to this question ? – biogirl Apr 29 '14 at 15:41
i will if i find time.. have stuff to do today.. if you found the answer then answer it yourself.. – WYSIWYG Apr 30 '14 at 3:45

1 Answer 1

Kinetochore (KT) is a multilayer protein complex. It's main function is to link chromosomes to the positive ends of the spindle microtubules. Also it plays role in the formation of heterogenic region at and around the centromer. The attachment of the KT is not uniform among living species. According to this paper on KT assembly in yeast:

. ... KTs remain attached to the MTs throughout the cell cycle in this organism. However, a temporary detachment of chromosomes from MTs occurs (for 1–2 min) at the time of CEN DNA replication in S phase in S.cerevisiae (Kitamura et al. , 2007). After completion of CEN replication, a KT reassembles and reestablishes its attachment with MTs.

source: (CEN - centromere, MT- (spindle)microtubules)

Thus the exact time of kinetochore attachment depends on the organism, though I must note that S. cerevisiae has somewhat different mitosis than us.

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