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At least one of the journal articles that reported on such clinical trials allured to the nicotinamide-tryptophan pathway that I assume must be related to the metabolism of tryptophan into serotonin since at least one of these journal articles placed some emphasis on the serotonin hypothesis of depression.

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Although nicotinamide is a vitamin - lack of it causes Pellagra in humans and Black-Tongue in dogs - it may also be synthesized from tryphophan, but in some dietary conditions not in sufficient amounts. (Pellegra was at one time a major disease). Perhaps that is what is meant? (As regards nicotinamde and Pellegra, this reference by Elvehjem is very good, if you are interested in the history). (Is your link OK?) – TomD Sep 11 '13 at 14:16

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