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There are several promising techniques for connectomics based on iterative sectioning and imaging of tissue with scanning electron microscopes (e.g. FIB-SEM and ATUM)

By looking at such micrographs, one can identify synapses:

    enter image description here

Is there any way to measure synaptic strength using these types of techniques?

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i guess you cant determine synaptic strength by just detecting synapses.. perhaps by labeling the receptors you might be able to say something using confocal.. there are some studies like that – WYSIWYG Sep 27 '13 at 16:47
    
Thank you @WYSIWYG. Would you mind pointing me to some of those papers? – Josh Sep 27 '13 at 17:38
    
I am sorry.. I don't know of papers. I just heard them in some talk.. i shall look up and get back.. – WYSIWYG Sep 28 '13 at 5:01
    
@WYSIWYG: I would be extremely wary of using such approach... you should really combine it with some ephys. – nico Sep 28 '13 at 7:38
    
@nico: totally agree on that.. i just said that there are some studies which check protein activity at the synapses using labelled proteins. It is not absolute.. Btw i still need to find reference for it. – WYSIWYG Sep 28 '13 at 10:48

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