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Is there a classification of methods for inferring genetic interactions? I mean some work published, utilizes genetical genomics data. Is this possible with expression data alone? And how about perturbation screens? I guess they all need information about mutants/genetic variations?

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The questions is vague and difficult to answer because there "genetic interactions" is a catch-all bag for anything that isn't a monogenic trait - which is to say, most of them. –  Superbest Apr 2 at 21:27

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BioGRID is an interaction database, and they catalogue interactions by (among other things) the class of experiment that discovered them. See http://wiki.thebiogrid.org/doku.php/experimental_systems#genetic_interactions

Other than that, you should look at recent reviews and publications, but you will easily get lost unless you figure out some important particulars, like:

  • What species? Yeast, worm, human, cell line?
  • What sort of interaction? Synthetic lethality? Complicated, fancy epistasis?
  • How much? Genome-wide? 2-3 genes?
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