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Is there a classification of methods for inferring genetic interactions? I mean some work published, utilizes genetical genomics data. Is this possible with expression data alone? And how about perturbation screens? I guess they all need information about mutants/genetic variations?

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The questions is vague and difficult to answer because there "genetic interactions" is a catch-all bag for anything that isn't a monogenic trait - which is to say, most of them. – Superbest Apr 2 '14 at 21:27

BioGRID is an interaction database, and they catalogue interactions by (among other things) the class of experiment that discovered them. See

Other than that, you should look at recent reviews and publications, but you will easily get lost unless you figure out some important particulars, like:

  • What species? Yeast, worm, human, cell line?
  • What sort of interaction? Synthetic lethality? Complicated, fancy epistasis?
  • How much? Genome-wide? 2-3 genes?
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