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There was some experiment in which a S phase cell was fused with other cell and the other cell also began to replicate DNA. Would the same happen if fused with nerve cell ? Why or why not?

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fusing cells is not feasible in all cases (it also causes polyploidy).. cells are immortalized by using oncogenes.. – WYSIWYG Oct 7 '13 at 18:58
you can also look at this post – WYSIWYG Oct 7 '13 at 19:06
Just an addition to the WYSIWYG's answer: phenomenon of neuronal de-differentiation under the influence of oncogenes was shown. – har-wradim Oct 8 '13 at 18:12

This specific experiment has not been done. Fusing cells is difficult and it also leads to polyploidy. Cells are immortalized by overexpressing oncogenes (or viral replication genes); for example HEK293 cell line was established by transforming embryonic kidney cells with adenovirus.

Now transforming a neuron would immortalize it but would also make it lose its function; for a cell like neuron, replication would compromise its activity for e.g. loss of established synapses. As mentioned in the comments by har-wradim, it was shown that transforming neurons with oncogenes leads to their de-differentiation. Another experiment of transforming neurons gave a contrasting result. Feddersen et al transformed purkinje cells in mice by expressing SV40 viral t-antigen from a purkinje-cell specific promoter and surprisingly it lead to degeneration of cerebellar tissue. Also have a look at this article.

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