Take the 2-minute tour ×
Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. It's 100% free, no registration required.

I heard the hypothesis, that the (main) reason of aging is the increasing number of mutations in body tissues. The higher the number of mutations is, the older tissue is.

Is this true? And how well supported is the idea?

Have somebody measured the numbers of mutations in different tissues at different ages, and if so, where I can get these numbers?

share|improve this question
add comment

1 Answer 1

I think telomere shortening largely accounts for the replicative cell aging. http://www.ncbi.nlm.nih.gov/pubmed/22901253 The increase in no. of mutations with age surely does affect the tissue/organism survival too. There's a recent study that I'd like to share here. It is quite interesting and informative. http://www.iflscience.com/health-and-medicine/mutations-found-115-year-old-womans-blood-could-help-unlock-secrets-aging

share|improve this answer
    
The article says telomeres are shortening in stem cells too (par. 5 end). Is this true? I read stem cells have telomerase working, which is preventing telomere shortening? –  Suzan Cioc May 2 at 8:40
add comment

Your Answer

 
discard

By posting your answer, you agree to the privacy policy and terms of service.

Not the answer you're looking for? Browse other questions tagged or ask your own question.