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Martin Nowak in his book "Evolutionary Dynamics" talks about a given correlation between genome size and mutation rate.

What correlation does exactly exist between these two concepts?

  • Is it a linear correlation?

  • What is the coefficient of correlation?

  • Does this correlation exist in many different taxa?

One will need to make whether we talk about mutation rate per base per generation or for the whole genome.

Some references to accompany claims are welcome!

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Could you provide a reference for the first sentence of the question, or is it an opinion? And what are the units of mutation rate- is it mutations per bp per generation? Or are we talking somatic mutations? –  Alan Boyd Nov 2 '13 at 17:48
I read about this correlation in Nowak's book "evolutionary dynamics". I am sorry I don't have a better reference right now. Good point! Yes I meant mutation rate per base pair per generation. And generation time is correlated with genome size. Let me rephrase completely my question in order to not assume this correlation. –  Remi.b Nov 2 '13 at 17:55
@AlanBoyd I'll ask the "why" part of my question in another post depending on the answer to this post. –  Remi.b Nov 2 '13 at 18:02
its probably not a linear relationship to genome size because larger genomes don't necessarily have –  shigeta Nov 3 '13 at 2:00
Drake proposed an inverse correlation between genome size and mutation rate A constant rate of spontaneous mutation in DNA-based microbes.. His rule seems to be true for DNA viruses (this is probably also interesting for the other thread on this). The paper has some kind of a follow-up for higher organisms (I have so far only read the abstract):"The mutation rate and cancer." –  Chris Feb 19 at 23:05
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