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When drugs such as Donepezil and Huperzine A are ingested, they travel through the blood stream, finally reaching vital neural receptors. Drugs like these inhibit the acetylcholinesterase enzyme responsible for breaking down acetylcholine causing an increase in ACh. This rise in ACh is correlated with deeper REM sleep cycles which therefore improves memory. After taking a capsule of Huperzine (150 mcg) one night, I found no apparent changes. Has anybody else who has had experience with these drugs found a drastic change?

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closed as primarily opinion-based by jonsca, Satwik Pasani, Amory, biogirl, fileunderwater Nov 14 '13 at 11:04

Many good questions generate some degree of opinion based on expert experience, but answers to this question will tend to be almost entirely based on opinions, rather than facts, references, or specific expertise.If this question can be reworded to fit the rules in the help center, please edit the question.

If you are looking for a readily apparent increase in REM cycle "intensity", stick on a nicotine patch before going to sleep. Vivid/Intense dreams are a well known side effect of nocturnal administration of direct neuronal nAChR agonists. I don't know of any research concerning dreams and ACh-ase inhibitors. –  Andrew Bonnell Nov 13 '13 at 14:44

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