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Where in the body are self antigens important? In terms of central tolerance and autoimmunity, but also in terms of T cell activation?

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Could you clarify a bit? What do you mean by important? Most problematic? Most relevant? I assume the body you refer to is the human one? –  terdon Dec 19 '13 at 11:33
    
This was a question in a PhD defense so I can only add my own interpretation. It's in the mouse and by important I mean anything really, relevant for proper development, where defects may lead to autoimmunity, and/or poor activation...I'm not entirely sure. –  DunjaM Dec 19 '13 at 17:26
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