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Only one side of the DNA ladder is copied (the sense side). The sense side starts with a 3’ end. This means the corresponding mRNA will have to assemble starting from the 5’ end. This is my initial thought, but can someone expand on it? Also, is this explained by why replication is performed in the 5' to 3' direction as suggested by this thread: Why is DNA replication performed in the 5' to 3' direction?

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Is the DNA template strand the same as the DNA sense strand? –  Cloud Dec 21 '13 at 1:35
    
No. Suppose your mRNA sequence from 5'to 3' is AGUC. Then, TEMPLATE strand is 3'-TCAG -5' but coding and sense strand is 5'AGTC3' i.e. complementary of the template strand and to the mRNA. This is a bit tricky so let someone else confirm this.... –  biogirl Dec 21 '13 at 3:56
    
It seems as though the nomenclature for DNA sense and template strand can be same or differentiable as suggested by this: sci.sdsu.edu/~smaloy/MicrobialGenetics/topics/… –  Cloud Dec 21 '13 at 4:31
    
it is not about RNA or DNA.. the chemistry of the polymerases and the substrates (NTP) cause this directionality. –  WYSIWYG Dec 21 '13 at 7:01
    
I had read about template,sense and coding from here –  biogirl Dec 21 '13 at 10:14

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