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Why does thyroid gland enlarge both in hypothyroidism and hyperthyroidism?
Hypothyroid goitre is due to lack of iodine in diet and hyperthyroid goitre (Exopthalmic goitre, Grave's disease) is due to oversecretion of thyroxine, or Thyroid stimulating Hormone. How does these two apparently opposite effects produce similar physical manifestation of the disorder (symptom) i.e is the enlargement of the thyroid gland?

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I would bet it has to do with retaining water and/or minerals. –  fredsbend Jan 14 at 0:55
    
Check this out. It is a very similar question. –  biogirl Jan 15 at 13:37
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