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If there is bacteria, lets say Enterococci that is sensitive to:

  • Amoxycillin-Clavulinic acid
  • Ampicillin-Sulbactam
  • Ofloxacin
  • Ciprofloxacin

Is it possible to become resistance to Ampicillin-Sulbactam by using Amoxycillin-Clavulinic acid ?

Is it possible to become resistance to Ofloxacin by using Ciprofloxacin ?

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It depends on the mechanism of resistance.. –  WYSIWYG Jan 20 at 4:17
    
Yes, via point mutations, which can happen spontaneously and doesn't depend on anything. –  Sam Jan 21 at 5:36
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