If father has hemophilia, mother is a carrier of the disease, then what is the probability of having a normal daughter ?
My question: Should the probability of having a daughter be also multiplied ? Should the answer be 0.5 or should it be 0.25 ?
I can't understand what you mean by "Should the probability of having a daughter be multiplied?" But yes, the probability of having a normal daughter is 0.25, but she will be a carrier like her mother.
Let H represent normal allele for blood clotting (dominant); h represent allele for hemophilia, XY represent the male chromosomes and XX represent the female chromosomes.
Parental Phenotypes :
Parental Genotypes (2n) :
Gametes (n) :
Possible Outcomes :
X(H)X(h) - A normal female, carrier.
X(H)Y - A normal male.
X(h)X(h) - A hemophiliac female.
X(h)Y - A hemophiliac male.
So probability of having a normal daughter, that is X(H)X(h) is 0.25.