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I found this sentence in my notes interesting

E-NOS and n-NOS are Ca, calmoduline dependant ferments. They are synthesized from in small conc as response to physiological signals which $\uparrow$ level of Ca2+ in cell.

Does it mean that e-NOS and n-NOS are synthesized by mediation of Ca and calmodulin?

I do not understand this part [e-NOS and n-NOS] are synthesized from in small conc as response to physiological signals ... What is conc?

I remember how RNS can be derived from nitric oxide and superoxide. Are e-NOS and n-NOS expressed on macrophages after induction by cytokines and microbial products, notably interferon-gamma and lipopolysaccharide?

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