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Extradistestinal disease seems to prefer to "bowel" diseases, I think this is about diseases outside gastrointestinal tract so stomach.

Consider diseases ulcerative colitis and Crohn's disease (enteritis) as examples. Colitis affects to colon, outside of small intestine, I think extraintestinal therefore. Crohn's disease (enteritis) however affects to the small intestine so I would think intestinal disease (but this clause is wrong) - it should be at least have extraintestinal manifestations.

What is the exact definition of the word extra in intestinal diseases?

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up vote 3 down vote accepted

Certain intestinal diseases have symptoms that appear concurrently in other systems of the body, but the bowel diseases themselves are not extraintestinal.

Extraintestinal manifestations of inflammatory bowel disease are prevalent in both ulcerative colitis and Crohn's disease. The most common manifestations involve the musculoskeletal and dermatologic systems. Other manifestations involve the hepatopan-creatobiliary system (eg, primary sclerosing cholangitis) as well as the ocular, renal, and pulmonary systems1.

One of the key differences between extraintestinal manifestations and comorbid conditions (though seemingly not a necessity, the article cites primary sclerosing cholangitis as an counterexample) is that the extraintestinal effects will subside once the disease of the bowel is treated.

1 Levine, J.S., Burakoff, R. (2011). Extraintestinal Manifestations of Inflammatory Bowel Disease. Gastroenterol Hepatol (NY), 7(4), 235–241.

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Does there exist any extraintestinal disease with some type of diarrhea? – Masi Feb 13 '14 at 9:42
@Masi In that case, the manifestation wouldn't be extraintestinal, it would be directly related to the intestine. – jonsca Feb 13 '14 at 11:06

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