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what kind of Pathway mediates nitroglycerin-induced relief from angina pectoris,please provide some idea...

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closed as off-topic by Chris, MattDMo, WYSIWYG, kmm Feb 21 '14 at 14:49

This question appears to be off-topic. The users who voted to close gave this specific reason:

  • "Homework questions are off-topic on Biology unless you have shown your attempt at an answer. For more information, see our homework policy." – MattDMo, WYSIWYG, kmm
If this question can be reworded to fit the rules in the help center, please edit the question.

This looks like a homework question. Can you please show what you have done so far to find an answer? – Chris Feb 20 '14 at 20:11
@Chris I missed my class so I really had no idea how to approach this question I did some literature search but it was confusing .. – krushna Feb 20 '14 at 20:24
up vote 3 down vote accepted

The effect of nitroglycerin on the cardiac tissue is similar to nitric oxide (NO), which forms in the endothelium of blood vessels from arginin metabolism products.

So, the general scheme can look like this:

R-NO2 is converted to R-NO outside of the cell (glutathion-SH-dependent reaction). NO is lipophilic and rapidly penetrates into the cell where it activates guanylate cyclase. From this moment you can see the resulting influence on myosin and actin on this picture:

muscle relaxation NO related

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