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The host response involves at least phagocytosis and probably localised acute inflammatory response at least after the colonisation.

I am thinking how the host can defend against pneumolysin which helps the streptococcus pneumoniae invasion.

How can the host defend against Streptococcus pneumoniae capsule?

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According to the two papers listed below, this is mostly done by a neutrophilic inflammatory response. The response is regulated by mechanisms of the innate immune system and is mediated by receptor like TLR2, TLR4 and SIGN-R1.

There are a few papers which go deeper (reviews, so you will probably have to go through the reference lists):

This paper mentions specific antibodies later on in the reaction and finally the opsonization by immune cells.

These two papers tal specifically about pneumolysin:

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This seems to be localised acute inflammation what they describe. Probably, first fibrous type of acute inflammation. –  Masi Mar 6 at 5:49
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@Masi I expanded my answer. –  Chris Mar 7 at 21:35

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