I've reading about proteomics and how it can be used with mass spectrometry to sequence digested peptides.
Reading this paper the author states (in box 2):
peptide fragmentation induced by collisions with residual gas, and bond breakage mainly occurs through the lowest energy pathways - that is, cleavage of the amide bonds
Why is cleavage predominately at the amide bond? What makes the amide bond the lowest energy pathway?