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When humans get the common cold, a common symptom is a stuffy or runny nose. Is that the body's immune response or is that the virus's doing?

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I don't have a reference for this, but I believe it's because of the viral shedding that occurs in the sinuses. –  leonardo Mar 27 '12 at 22:51
Interesting. I haven't heard that before. A similar but unrelated question is: biology.stackexchange.com/q/445/238 –  Gabriel Fair Mar 28 '12 at 1:25
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2 Answers

It's mainly caused by swelling of large veins and by an increase in vascular permeability that leads to an accumulation of fluids in the nasal mucosa. These effects are mediated, at least in part, by bradykinin and histamine, and can be counteracted by epinephrine. These mediators are part of the immune response to the viral particles.

You can read more about it here:

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The stuffiness is due to edema or swelling of the mucous membrane covering the nasal cavity. The swelling is caused by vasodialatation or dialatation of the capillaries and leaky vessels which accumulate fluid within the mucous membrane. The runny nose is mainly due to hyperactivity of the mucous cells of the lining which causes vastly more secretion than normal, triggered by the inflammatory reaction to the infection.

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