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As telomerase works by adding new nucleotides complementary to the RNA it contains, it cannot work for the complementary strand.

Say telomerase X has RNA complementary to the 5' to 3' strand it cannot elongate he telomere for the 3'to 5' strand.

So does a cell have 2 types of telomerases ? One for 5' to 3' and another for 3' to 5' ?

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up vote 2 down vote accepted

A second telomerase is not necessary, as the lagging strand is filled in by the DNA-Polymerase, see this figure:

enter image description here

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Awesome!thank u so much. – biogirl Mar 17 '14 at 3:24

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