Take the 2-minute tour ×
Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. It's 100% free, no registration required.

I think CVC cannot lead to heart failure primarily. So let's think its pathogenesis in skin now only.

I think the pathogenesis is like this

  • dilation of veins and capillaries due to impaired venous drainage
  • reduced outflow of blood from a tissue
  • passive process
  • $\to$ local increase in blood volumes
  • $\to$ local increase in venous pressure
  • pathological
  • $\to$ shortage of oxygen and built-up metabolic waste
  • $\to$ structural changes in microvasculature
  • $\to$ increased venous permeability % hallmark of acute inflammation
  • $\to$ increased size of venous caliber
  • $\to$ emigration of leucocytes
  • $\to$ accumulation at site of injury
  • activation of acute inflammation
  • $\to$ protein into extravascular space
  • $\to$ increased viscosity of blood
  • $\to$ deoxygenated blood blood stasis
  • $\to$ congested tissue
  • $\to$ leucocytes move to endothelial wall (selectins)
  • $\to$ roll
  • $\to$ adhere (integrin to stop)
  • $\to$ migrate
  • $\to$ dysky reddish-bluish skin (cyanotic)
  • $\to$ healing via fibrosis
  • $\to$ scar
  • Causes: venous thrombosis; venous compression; heart failure;

I am not sure about the role of leucocytes exactly in this process. I am not sure if they play a big role in the formation of cyanotic skin. I think the outcome is mostly because of increased vascular permeability and its deoxygenated blood in extracellular space.

What is the right pathogenesis of chronic venous congestion in skin?

share|improve this question
    
I extended this question to lungs to understand CVC enough well: biology.stackexchange.com/questions/15874/… –  Masi Mar 17 at 12:53
add comment

1 Answer 1

up vote 0 down vote accepted

Probably so simple answer is enough

  • acrocyanosis (manifestation of heart failure) which lead to distant (acro - distant) cyanosis, bluish skin.
share|improve this answer
add comment

Your Answer

 
discard

By posting your answer, you agree to the privacy policy and terms of service.

Not the answer you're looking for? Browse other questions tagged or ask your own question.