Blood donation involving apheresis is becoming increasingly common. It looks like the process involves centrifuging blood at very high speeds* before removing the desired fraction and returning the rest to the donor. Is there good reason to believe that the centrifuging process is harmless to all the various cells, proteins, lipids, and other substances in whole blood? Or is it possible that some blood constituents are damaged or altered?
* I don't know if the speeds are particularly high compared to other biomedical processes, but they're drastically outside the conditions in which biological products evolved to function, hence my question.