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Could a culture of cells of a certain type be 'forced' to attain certain properties in successive generations that would have been harmful to the cell culture as they are now?

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I am not sure, if I understand your question right. You want to know if a cell culture can be changed in a way, that it survives conditions in later generations, that were harmful to the cells before the change? –  Chris Apr 17 at 5:33
    
I'm wondering if the cell culture can be changed so all the resulting daughter cells have some new inherent properties that would have been harmful to the former cells (if the former cells could have had these properties). And this not necessarily involving external conditions.. –  user128932 Apr 17 at 5:48
    
Still a bit unclear to me. For example you can slowly diminish the amount of water in their environment and after some generations you cells might be able to live in a very dry environment while their ancestors could not. Yes this is possible, it is evolution. Or you might mean something like: Because the genetic background had changed over the course of some generations, a mutation that would have been deleterious is now well tolerated (fitness landscape). –  Remi.b Apr 17 at 7:26
    
Could the cell culture be changed after generations so they develope necessary functions that couldn't have existed in an ancestor cell without some of it's nesessary functions being temporarily 'shut down'. Forgive my amateur theorizing. –  user128932 Apr 19 at 5:34

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