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When considering the introduction of 4CMenB vaccine, the Joint Committee on Vaccination and Immunisation said:

The sub-committee noted that the clinical trials data suggest that when 4CMenB vaccine is given concomitantly with other routine childhood immunisations a substantially increased frequency of vaccine-induced fevers should be expected. Vaccine-induced fever rates may be similar to those associated with whole cell pertussis vaccine used in the past.

What is the likely explanation for the higher rate of fever for 4CMenB in comparison with other vaccines?

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