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I am studying Montelukast here:

Montelukast is more than 99% bound to plasma proteins. The steady state volume of distribution of montelukast averages 8 to 11 liters. Studies in rats with radiolabeled montelukast indicate minimal distribution across the blood-brain barrier. In addition, concentrations of radiolabeled material at 24 hours postdose were minimal in all other tissues.

which says that its distribution of steady state volume averages 8-11 liters. So there are environments where no montelukast exist. I am thinking what these environments can be:

  • is montelukast distributed homogenously in ECF intravascular?
  • is montelukast distributed mostly in the immediate environment of the membranes surrounding ECF?
  • can there be empty spaces in the distribution of montelukast, like indicated by the following figure?

enter image description here

where 3-6 liters of ECF is without montelukast, while 8-11 litres have montelukast bound to plasma proteins.

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