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From Lehninger Principles of Biochemistry :

The stability of YAC increases with size (up to a limit). Those with inserts of less than 100000 are gradually lost during mitosis.

Why does this happen ?

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just guessing: perhaps small YACs have problem during mitotic segregation (too small for the cohesin and kinetochore assembly) –  WYSIWYG May 2 at 6:40
    
From The world of the cell by becker : Infact, YAC must carry at least 50000bp to be reliably replicated and segregated. This supports @WYSIWYG guess. –  biogirl May 2 at 16:33
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