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A benign tumor has an outer layer of cancerous cells beyond which are regular cells (I Think). The Tumor must have some kind of boundary layer like a wall where somehow the cancerous cells can't affect any more normal cells outside the wall. A Benign Tumor I think can be inactive for many months; it might never grow anymore. Might it be that the cancer cells at this Benign Tumor Wall are inhibited from affecting any more cells? Could there be an Apoptosis shut-off inhibitor or a cell-death pathway shutting-off inhibitor in this case?

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Immune system fights cancer ... – biogirl May 6 '14 at 7:25
Are inhibitors part of the immune system? – user128932 May 8 '14 at 7:14
There are some cells...I think NK NK cells on wikipedia – biogirl May 8 '14 at 13:17

The primary difference between a benign tumor and a malignant tumor is that the former cannot metastasize; therefore they remain within the tissue boundaries.They grow slowly and are are not very de-differentiated thereby retaining some of the tissue organization.

Another point to be considered is that benign tumors do not cause vascularization (formation of blood vessels in the tumor tissue; triggered by secretion of VEGF), which also limits its growth.

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I think the first part of your answer is more a definition than a mechanism. In addition, I thought benign tumors were bound within a certain structure that prevented them from growing out of control and from metastasis (I am definitely not an expert!) Perhaps a reference would be in place in your answer? – Christiaan Dec 31 '14 at 12:39
@ChrisStronks Yes it is a definition only. I cannot find a reference for the wall preventing its overgrowth. Metastasis happens because of a cellular differentiation event (such as EMT). It is not a wall that restricts the escape of the rogue cell. I need to add references, I am looking for a proper one. – WYSIWYG Dec 31 '14 at 12:42
Does a benign tumor have some chemical or gene expression that blocks the secretion of VEGF? – 201044 Mar 29 '15 at 5:15
Is a benign tumour unable to metastasize because it can not cause vascularization (and then maybe there is no oncogenesis)?. Also does the apoptosis mechanisms in a benign tumour still 'work'? – 201044 Nov 25 '15 at 3:46

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