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Assume you have a case of young female where the intake of 75 grams of pure sugar leads to

  • a rapid peak of blood glucose level (within seconds)
  • plateau phase with very steady blood glucose level (many minutes)
  • another rapid peak of blood glucose level

There is no pathologies in her. This kind of behaviour occurs in all of her relatives too. So it must be with genetics.

Normal blood glucose regulation should be

  • steadily increasing blood sugar level
  • maximum
  • rather rapidly decreasing blood sugar level (since pure sugar)

where the mechanism are

  • neuronal innervations - membranes become more permeable to glucose, ions (K+, Mg+), for instance.
  • Na-K ATPase is activated
  • Ca2+ pump is depressed

My intuition what is happening in the abnormal case because of probably too few neuronal innervations, since steady changes of blood sugar level do not occur:

  • No reaction to glucose in blood, but only after it reached high level. The very fast control mechanism of changing membrane permeability is not working (neuronal innervation one reason).
  • The plateau phase, like the one with fast action potential of the heart's pacemakers), where much voltage-gated Calcium channels are closed which then depolarises the membrane and puts Na-K ATPase to work (note reverse way of working than in the normal case).
  • Another rapid increase in the blood sugar level after plateau.
  • After maximum, slow steady decrement in the blood sugar level; like the normal initial permeability -mechanism of membranes working, only now! Those too few innervations can only cause action potentials at high loads.

I call this kind of behaviour, the reverse insulin cascade; because some insulin effects occur in the reverse order. My explanation for it is

  • the existence of few innervations in the cell membranes. So beta cells activates only through “recovery Ca2+ mechanism” first.

What can cause this kind of reverse order in the blood glucose regulation? I am not sure if this is diabetes, because I am not sure if it can be heretical. The behaviour also does not remind me of diabetes. Something else seems to be going on.

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