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What is the role of different forms (filamentous and spherical) of HBV? Both forms are made exclusively of HBsAg. The filamentous form contains just much more (200 nm length), while 20 nm length for spherical. Dane particles are then again rare cases; 42 nm; I think also consists exclusively of HBsAg.

Now, I am thinking about which role the different antigens (HBsAg, HBcAg and HBeAg) play in the development of disease.

I know from Clinics that you can use these forms to make the diagnose to differentiate between acute, recovery and chronic forms. Therefore, I would say just that you have different forms in different stages of the disease:

  • Acute HBsAg(+), HBeAg(+)
  • Window Anti-HBeAg(+), anti-HBsAg(-), anti-HBcAg IgM(+)
  • Recovery HBsAg(-), anti-HBsAg(+), total anti-HBc(+)

but how these antigens work is much unknown to me.

What is the role of antigens of HBV in development of disease?

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