I found this claim in my study materials with explanation of amyloi plaques, in comparison to CJD (Creutzfeldt-Jakob Disease).
Its characteristic are
- Long doubling time of at least 5.2 days (I think this means the time it takes to double the amount of prions in the target organ)
- NO Cypopathic Effect (CPE) in vitro
- Long incubation period (about 30 years)
- Vacuolation of neurons, amyloid-like plaques
- Deficient immunity
- Deficient immunoresponse
- Deficient Interferen (IFN) production
so this suggests me that the person with infection at a young age can have the disease then at an old age. Other possible agent could be virus, but it seems that prion is the major one.
Can Alzheimer's disease be caused primarily by Slow Prion infection?