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CD47 aka the "don't eat me" signal has recently been claimed to be expressed on all tumor cells. This doesn't seem to corroborate with other cell-biology experiments. On what other cells is CD47 expressed?

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up vote 2 down vote accepted

I don't know how extensive. Let's run a simple data query and find out: Go to GEO at NCBI. In the "Gene profiles" window, type CD47, and hit enter to launch the query. At the top of the resulting page, use the link labeled "Limits" to restrict the 7000+ results to human by entering the term "human" in the "DataSet organism" window. So, there are 3700+ results. Look through them to get an idea of which cell types and under which conditions CD47 is expressed.

Let's try a second method. Go to the BioGPS portal. Enter CD47 in the appropriate window and run the query. From the results, select the row with ID # 961 as this represents the human gene CD47. The resulting gene expression/activity chart for Hs (human) will show you in more general terms where CD47 is expressed.

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I can't give a comprehensive answer to this, but the CD proteins are found on white blood cells of various types. If you think about it its impossible that a surface protein could be only observed on cancer cells as cancer is a cell line which is a reproductive dead end. You can see on the geneatlas box on the lower right side of the page - its gene is expressed, at least to a small amount, on nearly every major tissue type.

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