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Do mitochondria use ATP in order make another ATP from glucose, or does it use another source of energy to convert glucose to ATP?

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up vote 2 down vote accepted

During ATP production through the citric acid cycle, some ATP is used to transport necessary molecules for the reactions.

  • piruvate molecules are actively transported into the mitochondrial matrix [2]
  • two NADH equivalents from glycolisis are transported into the mitochondrion and consume two molar equivalents ATP [1]
  • protons leakage across the mitochondrial membrane leads to reduced ATP from NADH and FADH2 [1]

In theory, one molar equivalent of glucose can generate 38 equivalents of ATP. The actual number is only 25 [1].


  1. Wikipedia contributors, "Citric acid cycle," Wikipedia, The Free Encyclopedia, (accessed June 26, 2014).

  2. Wikipedia contributors, "Mitochondrion," Wikipedia, The Free Encyclopedia, (accessed June 26, 2014).

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