Take the 2-minute tour ×
Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. It's 100% free, no registration required.

Ischemia is roughly defined as insufficient blood flow to a specific region of the body and in the literature it is generally considered as causing oxygen and glucose deprivation in the tissue and therefore cells. Can we induce ischemia by depriving cells from oxygen and glucose in the medium or does it require more than that and ischemia is more complicated?

edit: i know the definition of ischemia maybe i should have said 'mimick' instead of 'induce'. Anyway, here is the better version of my question:

Ischemia is defined as blood flow shortage in a tissue and it is one of the main causes of non-apoptotic cell death. In an article i was reading, the authors claim that they induced ischemia in the glucose-serum containing medium. Does this mean they deprived the cells from oxygen and thus mimicked ischemia? Is this the way to create ischemia in a cell culture? What other ways can there be? Should not cells also be deprived from glucose?

share|improve this question

1 Answer 1

Ischemia leads to tissular hypoxia and glycopenia due to an insufficient blood flow (e.g. due to atherosclerosis or thromboembolic diseases). Ischemia always result in hypoxia.

Hypoxia can occur without ischemia (e.g. due to anemia).

Tissular glycopenia can occur without ischemia (e.g. due to hypoglicemia).

Ischemia is a shortage in blood supply. Depriving cells form oxygen and glucose isn't the same as cutting their blood supply.

share|improve this answer

Your Answer

 
discard

By posting your answer, you agree to the privacy policy and terms of service.

Not the answer you're looking for? Browse other questions tagged or ask your own question.