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since the title seems self explanatory; It would be nice if anybody could provide a reference. I'm looking for a paper that I belive stated around 1.5 Mb but anything above will be cordialy welcomed. thanks a lot

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up vote 2 down vote accepted

I haven't found 1.5 Mb, but 1 Megabase. This is the case for the shh gene in chicken, where the enhancer element is located 1 Mb upstream. The original article can be found here:

There are two reviews which are also interesting in this context:

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thanks. I also have encountered 1 Mb and distances slightly above, but I'm specifically interested in the longest known functional distance in cis. it is not as easy as I thought since I have spend now several hours on ncbi/pubmed ... – pidoretroma Jul 4 '14 at 13:59
I can have an additional look later today. Do you have any idea in which organism or for which gene this has been described? – Chris Jul 4 '14 at 14:05
unfortunately i don't. i may belive belive it was in M.m - but then again if I remembered properly I would have found it by now. thanks again anyway – pidoretroma Jul 4 '14 at 14:08
this paper "Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation" at least states finding interaction-distances in the range of megabases... and leaves it at that. – pidoretroma Jul 4 '14 at 16:07
I stumbled upon a few of these claims but they never show data or have references for it. – Chris Jul 4 '14 at 16:48

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