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There are several items that relate to the concerted evolution between pairs of sequences (especially structural) rRNA as a consequence of physical interaction in tertiary, or even quaternary supramolecular structure. My question is focused mainly on analysis with which one can recognize that a change in one nucleotide in a sequence, is the result of the alteration in the other (compensatory mutation), because although an alignment is a good approximation, it generates curiosity some more refined algorithms can quantify the change between nucleotides caused by a compensatory mutation event?

Thank you very much in advance!

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put on hold as too broad by WYSIWYG, Bez, Chris, Cornelius, Remi.b Dec 14 at 17:12

There are either too many possible answers, or good answers would be too long for this format. Please add details to narrow the answer set or to isolate an issue that can be answered in a few paragraphs.If this question can be reworded to fit the rules in the help center, please edit the question.

Hi! I don't really understand what your question is. I can see the question mark but I am not sure this is a question. Also, your paragraph contains only two sentences. It is good to make post as simple as possible, using short sentences. Finally, although I don't understand what your question is, it seems to me that your question is too broad. –  Remi.b Dec 14 at 17:12