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There are several items that relate to the concerted evolution between pairs of sencuencias (especially structural) rRNA as a consequence of physical interaction in tertiary, or even quaternary supramolecular structure. My question is focused mainly on analysis with which one can recognize that a change in one nucleotide in a sequence, is the result of the alteration in the other (compensatory mutation), because although an alignment is a good approximation, it generates curiosity some more refined algorithms can quantify the change between nucleotides caused by a compensatory mutation event?

Thank you very much in advance!

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