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Assume that there are two different signals occurring on the ECG - during depolarization and repolarization in the standard ECG. I was advised not to use the standard ECG in measuring the exact electrical events during:

  • stages 0-2
  • 3-4

We can get data about the electric activity of neurons in vivo,

enter image description here

where some data about the electric activity of neurons is present. So my thought is that a similar technique could probably work with cardiomyocytes.

I estimate that there is about 18% uncertainty when using the standard ECG because of the peak in the stage 1 (Gibbs phenomenon) and those two complete different phases.

How can you measure Na/K channel activation at the membrane level?

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This is probably not possible in vivo, but there are various methods (voltage clamping, channel blockers) that you can use in vitro with individual cells and perhaps correlate the results with the aggregate activity of a larger piece of heart muscle. – jonsca Jul 16 '14 at 22:56
@jonsca I found that we can get data about the electric activity of neurons in vivo. So probably the same technique has been used with cardiomyocytes. – Masi Jul 17 '14 at 8:34

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