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Assume that there are two different signals going on in the ECG - during depolarisation and repolarisation in the standard ECG. I got an advice that do not use the standard ECG in measuring exactly the electric events during

  • stages 0-2
  • 3-4

We can get data about the electric activity of neurons in vivo:

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where some data about the electric activity of neurons. So a similar technique can probably work with cardiomyocytes.

I estimate that I get about 18% uncertainty by using the standard ECG because of the peak in the stage 1 (Gibbs phenomenon) and those two complete different phases.

How can you measure Na/K channel activation in membrane level?

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This is probably not possible in vivo, but there are various methods (voltage clamping, channel blockers) that you can use in vitro with individual cells and perhaps correlate the results with the aggregate activity of a larger piece of heart muscle. –  jonsca Jul 16 at 22:56
    
@jonsca I found that we can get data about the electric activity of neurons in vivo. So probably the same technique has been used with cardiomyocytes. –  Masi Jul 17 at 8:34

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