Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. It's 100% free, no registration required.

Sign up
Here's how it works:
  1. Anybody can ask a question
  2. Anybody can answer
  3. The best answers are voted up and rise to the top

for a simulation I am developing I would like to know how the actin network in neurites is distributed.

Is actin confined to the periphery or is the whole neurite shaft containing actin with a rather constant density?

If you have any papers backing up the one or the other view don't hesitate to pass the link.

Thanks for answering.

share|improve this question
does this help? ( – Bez Jul 22 '14 at 17:48
on first sight this paper only gives a 2D distribution of actin over the whole neuron or? I would like to know what you would see if you cut a neurite and subsequently look "into" the cross section. Is the actin only found on the outer part of the cross section or evenly distributed across the circle? – user3683367 Jul 22 '14 at 18:01
Just look at papers doing confocal microscopy/imaging of actin with z-stacking (z refers to the axis) since thats the main approach people use for 3D imaging and people also use delta vision microscope with z-stacking and deconvolution. – Bez Jul 22 '14 at 18:13
up vote 0 down vote accepted

Actin is required for the neurite architecture and is present throughout the shaft (along the direction of the neurite process)

See these images.

                                        enter image description here


   enter image description here


These are not from research papers but the sources are trustworthy.

share|improve this answer
From those images I would not deduce that the neurite shaft has a substantial actin skeleton but rather a small amount of "misguided" filaments. Is that right? – user3683367 Nov 22 '14 at 17:39
Why would you assume some misguided filaments? The region indicated as meshwork is essential for the structure. – WYSIWYG Nov 23 '14 at 15:21
In the second picture actin and tubulin are labeled. I cannot see any actin along the shaft except of growth cone areas. So there is no substantial amount of actin concentrated along the shaft. Or? – user3683367 Nov 25 '14 at 11:28
OK I didnt understand what you meant by shaft. I thought you were referring to the filopodial region. Yes actin is not abundant in the axonal regions – WYSIWYG Nov 25 '14 at 11:31

Your Answer


By posting your answer, you agree to the privacy policy and terms of service.

Not the answer you're looking for? Browse other questions tagged or ask your own question.