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Are there experimental studies that measure how a population of bacteria in continuous culture evolve when submitted to changes in the concentrations of metabolites in the culture media?

For example, what happens to the population if the glucose concentration is cut in half?

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closed as too broad by Chris, WYSIWYG, GriffinEvo, Cornelius, Bez Dec 14 at 17:41

There are either too many possible answers, or good answers would be too long for this format. Please add details to narrow the answer set or to isolate an issue that can be answered in a few paragraphs.If this question can be reworded to fit the rules in the help center, please edit the question.

there are several such studies.. are you keen about evolution here? –  WYSIWYG Jul 23 at 6:06
@WYSIWYG I suppose there two ways a population can respond to changes in nutrient concentrations. The population can evolve, which means that some individuals will die and those adapted to the new conditions will be selected. Another possible response is that individuals that were adapted to the previous culture medium will adjust their metabolism to the new culture medium. The total response of the population is probably a combination of both. I am looking for references addressing this, from any of these points of view, or both. –  becko Jul 23 at 12:45
In case of usual metabolites, they don't die off. Yes it is possible that a certain mutant outgrows others. This kind of experiment has been done with some damaging chemicals like $H_2O_2$. It was in molecular systems biology journal. I'll search it and post the link. –  WYSIWYG Jul 23 at 15:17