Dr. Liisa Ukkola-Vuoti, University of Helsinki, Finland, done a detailed GWCNV(Genome-Wide Copy Number Variation) Analysis of certain group of people for musical creativity and aptitude.
Genome-Wide Copy Number Variation Analysis in Extended Families and Unrelated Individuals Characterized for Musical Aptitude and Creativity in Music
They did a Genome Wide Copy Number Variations (CNVs) in five extended
pedigrees and in 172 unrelated subjects characterized for musical
aptitude and creative functions in music
Muscial Aptitude is taken as Sum of Scores of Auditory structuring ability, Seashores test for pitch and for time. Along with data on creativity in music was surveyed using a web-based questionnaire.
- Several CNVRs containing genes that affect neurodevelopment, learning
and memory were detected.
A deletion at 5q31.1 covering the protocadherin-α gene cluster (Pcdha 1-9) was found co-segregating with low music test scores (COMB) in both sample sets. Pcdha is involved in neural migration, differentiation and synaptogenesis.
Creativity in music was found to co-segregate with a duplication covering glucose mutarotase gene (GALM) at 2p22. GALM has influence on serotonin
release and membrane trafficking of the human serotonin transporter.
Genes related to serotonergic systems have been shown to associate not only with psychiatric disorders but also with creativity and music perception.
Both, Pcdha and GALM, are related to the serotonergic systems influencing cognitive and motor functions, important for music perception and practice.
A 1.3 Mb duplication was identified in a subject with low COMB scores in the region previously linked with absolute pitch (AP) at 8q24.
No differences in the CNV burden was detected among the high/low music test scores or creative/non-creative groups.
In summary, CNVs and genes found in this study are related to
cognitive functions. Our result suggests new candidate genes for music
perception related traits and supports the previous results from AP
 Genome-Wide Copy Number Variation Analysis in Extended Families and Unrelated Individuals Characterized for Musical Aptitude and Creativity in Music
 Musical Aptitude Is Associated with AVPR1A-Haplotypes