I got experimental data where hypersensitivity (i.e. tonic pain when touching ear canal) was recognised for about 100 minutes.
I do not know which type of hypersensitivity is this one. IgM can reach ear canal, I think (not sure) - it is just in the limit. If IgM cannot reach ear canal, then the hypersensitivity must be caused by
- humoral immune system
which is responding slowly to the trigger.
It is proposed that this cannot be contact dermatitis because
- the reaction happened simultaneously in both ear canals
after irritating ear canals with plastic the subject is not allergic. Irritation was also a selected signal which resulted in the dynamic cycle of bass music by Beats earphones. It was studied the effect of the specific signal with bass music on the movement on the inner membrane on the subject with problem in maintaining the inner physiology of ear itself (also repeated cycle of ear infections during childhood).
Can IgM reach ear canal?
The hypersensitivity was simultaneous in both ear canals. I did not know before that you can get hypersensitivity reaction in ear canals and also simultaneously. I think hypersensitivity is not in normal condition. There must be some etiological factors (probably neuronal) that can cause it.
There are other organs which can have hypersensitivity too. So I started to think what is the trigger of hypersensitivity.
My conjuncture is about Secreted substances of endothelium (EDRF, EDCF). There are three types of substances secreted by the endothelium
- Endothelium hyperpolarising factors
NO is the most important one. But what is its role in the hypersensitivity of ear canal is unknown to me.
What is the mechanism of hypersensitivity of our body and particularly in the ear canal?