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I've read that CRISPR/Cas9 is currently being implemented and tested for its ability to edit genomes in live cells, and that it is supplanting other genome editing tools in labs, such as TALENs and Zinc finger nucleases.

I understand that there may be a few metrics used for analyzing any genome editing system. One is the efficiency, which could be measured perhaps in edits per time or edits per molecule. Another metric might be error-rate. What is the probability that a genome is altered in something other than the intended way? Another metric might be the length of the genome that may be edited at once.

I've also read that CRISPR/Cas9 evolved in bacteria. When did CRISPR/Cas9 evolve in the history of life on earth?

If CRISPR/Cas9 evolved in bacteria, and before other evolutionary advances, including some of those that may have enabled certain multiceullar forms of life, I have to wonder if other systems like CRISPR/Cas9 but superior to it in some metric evolved as well.

How does recombination in sexual reproduction work? Might it involve biomolecular machinery like that of CRISPR/Cas9?

How does the adaptive immune system work? How does VDJ recombination work? Does it involve an advanced (relative to CRISPR/Cas9) genome editing system?

How might one estimate the probability that a system superior to CRISPR/Cas9 exists already?

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could you further expand on the question and set out some parameters or perhaps share your thoughts or work on the matter so that any input is constructive. –  Bez Aug 21 at 18:53

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