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I'd like to know how antioxidants affect human metabolism and which ones are essential for metabolic processes.

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2 Answers 2

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This mainly depends on which kind of antioxidants you're talking about.

  • Vitamin A and E are antioxidants acquired from the food
  • Superoxide dismutase, Catalase and the Glutathione system are enzymes produced by the cell.

Antioxidants keep the oxidative balance of the cell and quench free radicals which are generated by the mitochondrial respiratory chain. Very simplified: Antioxidants are thought to be anti-ageing compounds because free radicals destroy cellular compounds, which can be related to the ageing process.

I would be very careful with products claiming to contain antioxidants and be therefore anti-aging. This whole anti-ageing marketing is far from being scientifically proven.

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so in answer to the OP, the antioxidants don't affect metabolism per se, but they are required for 'normal' functioning of a cell over a prolonged period of time, otherwise the cell would get damaged by free radicals? Which particular ones will likely be tissue/context specific I guess? –  Luke May 29 '12 at 12:19
    
The last question is not so easy to answer and AFAIK unknown. The first question is right, it's more on the cellular level. –  Eekhoorn May 29 '12 at 12:35
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@zenbomb is right. The essential exogenous antioxidants are vitamins. How they, and the non-essential ones affect the metabolism is an active area of research. zenbomb is especially right to warn you against commercial products (or particular foods) claimed to have health benefits. –  Ryan Apr 3 '13 at 23:51

Anti-oxidants affect human metabolism by altering the redox states of the cell and redox-regulated functions and signaling mechanisms.

The following quotes are from The Redox Stress Hypothesis of Aging (Free Radic Biol Med. Feb 2012)

More recently, in a major conceptual shift, ROS have been found to be physiologically vital for signal transduction, gene regulation, and redox regulation, among others, implying that their complete elimination would be harmful. An alternative notion, advocated here, termed the "redox stress hypothesis," proposes that aging-associated functional losses are primarily caused by a progressive pro-oxidizing shift in the redox state of the cells, which leads to the overoxidation of redox-sensitive protein thiols and the consequent disruption of the redox-regulated signaling mechanisms.

Many proteins contain cysteine residues which can undergo reversible modifications such as S-nitrosylation and S-glutationylation.

The redox state affects the oxidation levels of these redox-sensitive protein thiols and the consequent disruption in protein activity and the redox-regulated signaling mechanisms.

Under normal conditions the usual types of oxidation modifications of these protein thiols are reversible, and is a way to protect the thiol in transient periods of oxidative stress.

When the redox state shifts to a more oxidised point then more irreversiable protein thiol modifications occurs, i.e. damages the protein.

As shown in Figure 6, prolonged exposure of sulfenic acid, formed at the active or regulatory sites, to H2O2, sequentially leads to the formation of sulfinic- (−SO2H) and sulfonic-acids (−SO3H), which are deemed to be largely irreversible reactions. In addition, protein disulfides may undergo over-oxidation, leading to the formation of thiosulfenate and thiosulfonate, which are also believed to be relatively irreversible reactions. The level of oxidation of protein cysteinyl thiolates depends upon the strength (concentration) and the duration of exposure to H2O2.

Protein activity and enzyme catalytic efficiency which affects metabolism, such as sirtuins, are affected by the these thiol redox modifications. (eg SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress and A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress.)

The primary arbiter of redox state is glutathione, i.e. the GSH/GSSG couple. The effect of anti-oxidants appears to vary depending on whether it affects the redox state.

The antioxidant activities of SOD and catalase neutralize the ROS species, O2− and H2O2, without having a direct impact on glutathione redox state. However this frees up glutathione from having to neutralize the ROS species, which it can do so with the glutathione peroxidase enzyme.

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