Take the 2-minute tour ×
Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. It's 100% free, no registration required.

In regards to cancer why do cells replicate themselves? If it's a mutation, what kind of mutation would this be classified as?

share|improve this question
2  
I would rephrase the beginning of the question, if you agree. Right now it seems a bit "backwards". Cancer is defined as an uncontrolled growth of cells, so there is no specific reason (finality) for cancerous cells to grow. When a mutation causes cells to grow in an uncontrolled manner then you have cancer. –  nico Aug 17 '12 at 9:12

1 Answer 1

This article covers some of the key issues of cancer in layman's terms.

Essential, cancer is caused by multiple mutations in key regulatory genes which function in maintaining the cell cycle. This provokes uncontrollably rapid cell division, with only furthers the problem with genetic mutation. Here are some quotes from the article to strengthen your understanding in cancer cell mutations.

The cell cycle: Wikimedia Commons Image source

The cells become progressively more abnormal as more genes become damaged. Often, the genes that are in control of DNA repair become damaged themselves, rendering the cells even more susceptible to ever-increasing levels of genetic mayhem.

[...] Most cancers are thought to arise from a single mutant precursor cell. As that cell divides, the resulting 'daughter' cells may acquire different mutations and different behaviors over a period of time. Those cells that gain an advantage in division or resistance to cell death will tend to take over the population. In this way, the tumor cells are able to gain a wide range of capabilities that are not normally seen in the healthy version of the cell type represented.

[...] Mutations in key regulatory genes (tumor suppressors and proto-oncogenes) alter the behavior of cells and can potentially lead to the unregulated growth seen in cancer.

share|improve this answer

Your Answer

 
discard

By posting your answer, you agree to the privacy policy and terms of service.

Not the answer you're looking for? Browse other questions tagged or ask your own question.