Are there any intersections between the biochemical pathways of uracil biosynthesis (or metabolism) and methionine degradation in eukaryotes?

Question

Is there any way in which uracil biosynthesis or metabolism could help cell in degradation of toxic levels of methionine?

Answer 1

No, I don't think there are any intersections, and I can't see how uracil metabolism would have any influence upon methionine degradation.

Methionine degradation is shown in Figure 1 below. The end product is succinyl CoA which is fed into the TCA cycle. The only obvious by-product is cysteine which doesn't have any connection with uracil biosynthesis.

Uracil biosynthesis (as UMP) is shown in Figure 2: it is built from CO₂ and NH₃. Uracil degradation produces CO₂ NH₃ and aspartate.

There are certainly no shared intermediates in these pathways, and I can't come up with any convincing indirect connections either.

Figure 1. Methionine degradation

Figure 2. Uracil biosynthesis