If VX (a toxic agent) is given to a rabbit, typically would % Acetylcholinesterase (the target enzyme) inhibition drop very rapidly? Or would it taper off very slowly?
closed as not a real question by leonardo, Alexander Galkin Nov 26 '12 at 20:56
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VX is a Quasi-irreversible inhibitor of ACE meaning that after binding covalent bonds are created making dephosphorylation of ACE impossible. This would suggest to me that the function is not possible to restore. After inhibition of ACE by VX the ACE is permanently deactivated.
Irreversible inhibition does not typically use IC50 measures of the rate of inhibition. This means that the rate would very much depend on the concentration of the VX to the ACE target. However, a typical irreversible inhibitor would degrade target activity following exponential decay - i.e. dropping very rapidly and then tapering off slowly.