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How does the digestive acid (HCl) not burn the surrounding skin of our stomach? It digests majority of raw food we eat but how does it stays safe in our stomach? Also, how does the stomach retains the safety procedures for a human body to retain it for all lifetime ?

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What do you mean by "how does the stomach retain the safety procedures for a human body to retain it for all lifetime"? –  Orcris Jan 16 '13 at 19:34

2 Answers 2

up vote 7 down vote accepted

Mucous-producing cells at the neck of the gastric pits create a layer of protective mucous covering the stomach lining. This mucous layer includes bicarbonate ions which act as a chemical barrier against the protons in gastric juice. See here for some evidence.

I don't understand the second question; "Also, how does the stomach retains the safety procedures for a human body to retain it for all lifetime ?"

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Thanks Alan, what I meant was that how is the 'safety procedure=layer of protective mucus' retained for lifetime? Does it regenerates? –  Damien Joe Jan 17 '13 at 12:44
    
@Damien Joe - yes, the mucous layer is continuously replenished. –  Alan Boyd Jan 17 '13 at 13:10

Cause of this secret are tight junctions and mucous. As Wikipedia explains:

Tight junctions, or zonula occludens, are the closely associated areas of two cells whose membranes join together forming a virtually impermeable barrier to fluid. It is a type of junctional complex present only in vertebrates. The corresponding junctions that occur in invertebrates are septate junctions.

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They perform vital functions:They hold cells together.Barrier function, which can be further subdivided into protective barriers and functional barriers serving purposes such as material transport and maintenance of osmotic balance:They help to maintain the polarity of cells by preventing the lateral diffusion of integral membrane proteins between the apical and lateral/basal surfaces, allowing the specialized functions of each surface (for example receptor-mediated endocytosis at the apical surface and exocytosis at the basolateral surface) to be preserved. This aims to preserve the transcellular transport.They prevent the passage of molecules and ions through the space between cells. So materials must actually enter the cells (by diffusion or active transport) in order to pass through the tissue. This pathway provides control over what substances are allowed through. (Tight junctions play this role in maintaining the blood–brain barrier.) At the present time, it is still unclear whether the control is active or passive and how these pathways are formed. In one study for paracellular transport across the tight junction in kidney proximal tubule, a dual pathway model is proposed: large slit breaks formed by infrequent discontinuities in the TJ complex and numerous small circular pores.1In human physiology there are two main types of epithelia using distinct types of barrier mechanism. Dermal structures such as skin form a barrier from many layers of keratinised squamous cells. Internal epithelia on the other hand more often rely on tight cells junctions for their barrier function. This kind of barriers is mostly formed by only one or two layers of cells. Until recently it was not clear whether tight cell junctions also play any role in the barrier function of the skin and similar external epithelia, recent research suggests that this is indeed the case.

In the next step mucous protect epithelial cells from released HCl. Here you will find more things.

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Again it's best if quotes support your answer rather than form it in great part. –  Rory M Jan 16 '13 at 12:51
    
Ok, I will purpose, in future. –  MySky Jan 16 '13 at 13:32

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